2017 and beyond [Top]

  • Honkanen H, Oikarinen S, Nurminen N, Laitinen OH, Huhtala H, Lehtonen J, Ruokoranta T, Hankaniemi MM, Almond JW, Tauriainen S, Simell O, Ilonen J, Veijola R, Viskari H,Knip M, Hyöty H. Detection of enteroviruses in stools precedes the appearance of islet autoimmunity with a delay of several months – possible evidence for slowly operating mechanisms in virus-induced autoimmunity. Diabetologia 2017; 60: 424-431.
  • Hӓmӓlӓinen N, Nwaru BI, Erlund I, Takkinen HM, Ilonen J, Veijola R, Knip M, Kaila M, Virtanen SM. Serum carotenoid and tocopherol levels and risk of asthma in childhood: a nested case-control study. Clin Exp Allergy 2017; 47: 401-409.
  • Knip M, Siljander H, Ilonen J, Simell O, Veijola R. Role of humoral beta-cell autoimmunity in type 1 diabetes. Pediatric Diabetes 2016; 17, Supp. S22: 17-24.
  • Knip M, Selvenius J, Siljander H, Veijola R. Reclassification of asymptomatic beta cell autoimmunity: a critical perspective. Diabetologia 2017; 60: 39-42.
  • Knip M. Loss of β-cell mass: an acute event before T1DM presentation? Nature Rev Endocrinol 2017; 13: 253-254.
  • Hyötyläinen T, Ahonen L, Pöhö P, Orešič M. Lipidomics in biomedical research-practical considerations. Biochim Biophys Acta. 2017 Apr 10. pii: S1388-1981(17)30062-8. doi: 10.1016/j.bbalip.2017.04.002.
  • Tsagaratou A, González-Avalos E, Rautio S, Scott-Browne JP, Togher S, Pastor WA, Rothenberg EV, Chavez L, Lähdesmäki H, Rao A. TET proteins regulate the lineage specification and TCR-mediated expansion of iNKT cells. Nat Immunol. 2017 Jan;18(1):45-53.
  • Li Z, Khan MM, Kuja-Panula J, Wang H, Chen Y, Guo D, Chen ZJ, Lahesmaa R, Rauvala H, Tian L. AMIGO2 modulates T cell functions and its deficiency in mice ameliorates experimental autoimmune encephalomyelitis. Brain Behav Immun. 2017 May;62:110-123.
  • Moulder R, Bhosale SD, Lahesmaa R, Goodlett DR. The progress and potential of proteomic biomarkers for type 1 diabetes in children. Expert Rev Proteomics. 2017 Jan;14(1):31-41.
  • Martinez-Bravo MJ, Wahlund CJ, Qazi KR, Moulder R, Lukic A, Rådmark O, Lahesmaa R, Grunewald J, Eklund A, Gabrielsson S. Pulmonary sarcoidosis is associated with exosomal vitamin D-binding protein and inflammatory molecules.J Allergy Clin Immunol. 2017 Apr;139(4):1186-1194.
  • Pöllänen PM, Lempainen J, Laine AP, Toppari J, Veijola R, Vähäsalo P, Ilonen J, Siljander H, Knip M. Characterisation of rapid progressors to type 1 diabetes among children with HLA-conferred disease susceptibility. Diabetologia. 2017 Mar 31. doi: 10.1007/s00125-017-4258-7. [Epub ahead of print] PubMed PMID: 28364254.
  • Tuokkola J, Luukkainen P, Nevalainen J, Ahonen S, Toppari J, Ilonen J, Veijola R, Knip M, Virtanen SM, Kaila M. Eliminating cows' milk, but not wheat, barley or rye, increases the risk of growth deceleration and nutritional inadequacies. Acta Paediatr. 2017 Mar 27. doi: 10.1111/apa.13846. [Epub ahead of print] PubMed PMID: 28345135.
  • Koskenniemi JJ, Virtanen HE, Toppari J. Testicular growth and development in puberty. Curr Opin Endocrinol Diabetes Obes. 2017 Feb 28. doi: 10.1097/MED.0000000000000339. [Epub ahead of print] PubMed PMID: 28248755.
  • Hämäläinen N, Nwaru BI, Erlund I, Takkinen HM, Ahonen S, Toppari J, Ilonen J, Veijola R, Knip M, Kaila M, Virtanen SM. Serum carotenoid and tocopherol concentrations and risk of asthma in childhood: a nested case-control study. Clin Exp Allergy. 2017 Mar;47(3):401-409. doi: 10.1111/cea.12904. PubMed PMID: 28198577.
  • Mikk ML, Heikkinen T, El-Amir MI, Kiviniemi M, Laine AP, Härkönen T, Veijola R, Toppari J, Knip M, Ilonen J; Finnish Paediatric Diabetes Register.. The association of the HLA-A*24:02, B*39:01 and B*39:06 alleles with type 1 diabetes is restricted to specific HLA-DR/DQ haplotypes in Finns. HLA. 2017 Apr;89(4):215-224. doi: 10.1111/tan.12967. Epub 2017 Feb 10. PubMed PMID: 28185422.
  • Doroszko M, Chrusciel M, Belling K, Vuorenoja S, Dalgaard M, Leffers H, Nielsen HB, Huhtaniemi I, Toppari J, Rahman NA. Novel genes involved in pathophysiology of gonadotropin-dependent adrenal tumors in mice. Mol Cell Endocrinol. 2017 Mar 15;444:9-18. doi: 10.1016/j.mce.2017.01.036. Epub 2017 Jan 25. PubMed PMID: 28131743.
  • Viisanen T, Ihantola EL, Näntö-Salonen K, Hyöty H, Nurminen N, Selvenius J, Juutilainen A, Moilanen L, Pihlajamäki J, Veijola R, Toppari J, Knip M, Ilonen J, Kinnunen T. Circulating CXCR5+PD-1+ICOS+ Follicular T Helper Cells Are Increased Close to the Diagnosis of Type 1 Diabetes in Children With Multiple Autoantibodies. Diabetes. 2017 Feb;66(2):437-447. doi: 10.2337/db16-0714. Epub 2016 Oct 10. PubMed PMID: 28108610.
  • Asadi-Azarbaijani B, Santos RR, Jahnukainen K, Braber S, van Duursen MB, Toppari J, Saugstad OD, Nurmio M, Oskam IC. Developmental effects of imatinib mesylate on follicle assembly and early activation of primordial follicle pool in postnatal rat ovary. Reprod Biol. 2017 Mar;17(1):25-33. doi: 10.1016/j.repbio.2016.11.003. Epub 2016 Dec 28. PubMed PMID: 28040471.
  • Virtanen HE, Jørgensen N, Toppari J. Semen quality in the 21(st) century. Nat Rev Urol. 2017 Feb;14(2):120-130. doi: 10.1038/nrurol.2016.261. Epub 2017 Jan 4. Review. PubMed PMID: 28050014.

2016 [Top]

  • Chan YH, Intosalmi J, Rautio S, Lähdesmäki H, A subpopulation model to analyze heterogeneous cell differentiation dynamics, Bioinformatics, Vol. 32, No. 21, pp. 3306-3313, 2016.
  • Äijö T, Yue X, Rao A, Lähdesmäki H, LuxGLM: A probabilistic covariate model for quantification of DNA methylation modifications with complex experimental designs, Bioinformatics (ECCB2016), Vol. 32, No. 17, pp. i511-i519, 2016.
  • Domsgen E, Lind K, Kong L, Hühn MH, Rasool O, van Kuppeveld F, Korsgren O, Lahesmaa R, Flodström-Tullberg M. An IFIH1 gene polymorphism associated with risk for autoimmunity regulates canonical antiviral defence pathways in Coxsackievirus infected human pancreatic islets. Sci Rep. 2016 Dec 21;6:39378.
  • Rahkonen N, Stubb A, Malonzo M, Edelman S, Emani MR, Närvä E, Lähdesmäki H, Ruohola-Baker H, Lahesmaa R, Lund R. Mature Let-7 miRNAs fine tune expression of LIN28B in pluripotent human embryonic stem cells. Stem Cell Res. 2016 Nov;17(3):498-503.
  • Tuokkola J, Luukkainen P, Tapanainen H, Kaila M, Vaarla O, Kenward MG, Virta L, Veijola R, Simell O, Ilonen J, Knip M, Virtanen SM. Milk intake during pregnancy and lactation and cow’s milk allergy in offspring. Eur J Clin Nutr 2016; 70: 554-559.
  • Ilonen J, Kiviniemi M, Lempainen J, Simell O, Toppari J, Veijola R, Knip M, the Finnish Pediatric Diabetes Register. Genetic susceptibility to type 1 diabetes in childhood - estimation of HLA class II associated disease risk and class II effect in various phases of diabetes-associated autoimmunity. Pediatr Diabetes 2016; 17, Suppl S22: 8-16.
  • Galli E, Sainio M, Härkönen T, Ustav M, Urtti A, Yliperttula M, Lindahl M, Knip M, Saarma M, Lindholm P. Increased circulating concentations of mesencephalic astrocyte-derived neurotrophic factor in children with type 1 diabetes. Sci Rep 2016; 6: 29058.
  • Huopio H, Miettinen P, Ilonen J, Nykänen P, Veijola R, Keskinen P, Näntö-Salonen K, Raivo J, Stančáková A, Vangipurapu J, Männistö J, Kuulasmaa T, Knip M, Otonkoski T, Laakso M Clinical, genetic and laboratory characteristics of early-onset diabetes in the Finnish population. J Clin Endocrinol Metab 2016; 101: 3018-2025.
  • Tuokkola J, Luukkainen P, Kaila M, Takkinen H-M, Niinistö S, Veijola R, Virta LJ, Knip M, Simell O, Ilonen J, Virtanen SM. Maternal dietary folate, folic acid, and vitamin D intake during pregnancy and lactation and the risk of cow’s milk allergy in the offspring. Br J Nutr 2016; 116: 710-718.
  • Helminen O, Pokka T, Tossavainen P, Ilonen J, Knip M, Veijola R. Continuous glucose monitoring, self-monitored blood glucose and HbA1c in the evaluation of glucose metabolism in children at high risk for type 1 diabetes. Diabetes Res Clin Pract 2016; 120: 89-96.
  • Simre K, Uibo O, Peet A, Tillmann V, Kool P, Hämäläinen AM, Härkönen T, Siljander H, Ilonen J, Knip M, Uibo R, the DIABIMMUNE Study Group. Exploring the risk factors for differences in the cumulative incidence of celiac disease in two neighboring countries: the prospective DIABIMMUNE study. Dig Liver Dis 2016; 48: 1296-1301.
  • Da Ros M, Lehtiniemi T, Olotu O, Fischer D, Zhang FP, Vihinen H, Jokitalo E, Sironen A, Toppari J, Kotaja N. FYCO1 and autophagy control the integrity of the haploid male germ cell-specific RNP granules. Autophagy. 2017 Feb;13(2):302-321. doi: 10.1080/15548627.2016.1261319. Epub 2016 Dec 8. PubMed PMID: 27929729; PubMed Central PMCID: PMC5324852.
  • Lind DV, Main KM, Kyhl HB, Kristensen DM, Toppari J, Andersen HR, Andersen MS, Skakkebæk NE, Jensen TK. Maternal use of mild analgesics during pregnancy associated with reduced anogenital distance in sons: a cohort study of 1027 mother-child pairs. Hum Reprod. 2017 Jan;32(1):223-231. Epub 2016 Nov 16. PubMed PMID: 27852690.
  • Seppälä E, Sillanpää S, Nurminen N, Huhtala H, Toppari J, Ilonen J, Veijola R, Knip M, Sipilä M, Laranne J, Oikarinen S, Hyöty H. Human enterovirus and rhinovirus infections are associated with otitis media in a prospective birth cohort study. J Clin Virol. 2016 Dec;85:1-6. doi: 10.1016/j.jcv.2016.10.010. Epub 2016 Oct 20. PubMed PMID: 27780081.
  • Känsäkoski J, Jääskeläinen J, Jääskeläinen T, Tommiska J, Saarinen L, Lehtonen R, Hautaniemi S, Frilander MJ, Palvimo JJ, Toppari J, Raivio T. Complete androgen insensitivity syndrome caused by a deep intronic pseudoexon-activating mutation in the androgen receptor gene. Sci Rep. 2016 Sep 9;6:32819. doi: 10.1038/srep32819. PubMed PMID: 27609317; PubMed Central PMCID: PMC5016895.
  • Borges IC, Andrade DC, Cardoso MR, Toppari J, Vähä-Mäkilä M, Ilonen J, Knip M, Hyöty H, Veijola R, Simell O, Jartti T, Käyhty H, Ruuskanen O, Nascimento-Carvalho CM. Natural Development of Antibodies against Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis Protein Antigens during the First 13 Years of Life. Clin Vaccine Immunol. 2016 Nov 4;23(11):878-883. Print 2016 Nov. PubMed PMID: 27581439; PubMed Central PMCID: PMC5098021.
  • Antignac JP, Main KM, Virtanen HE, Boquien CY, Marchand P, Venisseau A, Guiffard I, Bichon E, Wohlfahrt-Veje C, Legrand A, Boscher C, Skakkebæk NE, Toppari J, Le Bizec B. Country-specific chemical signatures of persistent organic pollutants (POPs) in breast milk of French, Danish and Finnish women. Environ Pollut. 2016 Nov;218:728-738. doi: 10.1016/j.envpol.2016.07.069. Epub 2016 Aug 9. PubMed PMID: 27521295.
  • Vandenberg LN, Ågerstrand M, Beronius A, Beausoleil C, Bergman Å, Bero LA, Bornehag CG, Boyer CS, Cooper GS, Cotgreave I, Gee D, Grandjean P, Guyton KZ, Hass U, Heindel JJ, Jobling S, Kidd KA, Kortenkamp A, Macleod MR, Martin OV, Norinder U, Scheringer M, Thayer KA, Toppari J, Whaley P, Woodruff TJ, Rudén C. A proposed framework for the systematic review and integrated assessment (SYRINA) of endocrine disrupting chemicals. Environ Health. 2016 Jul 14;15(1):74. doi: 10.1186/s12940-016-0156-6. PubMed PMID: 27412149; PubMed Central PMCID: PMC4944316.
  • Ilonen J, Kiviniemi M, Lempainen J, Simell O, Toppari J, Veijola R, Knip M; Finnish Pediatric Diabetes Register.. Genetic susceptibility to type 1 diabetes in childhood - estimation of HLA class II associated disease risk and class II effect in various phases of islet autoimmunity. Pediatr Diabetes. 2016 Jul;17 Suppl 22:8-16. doi: 10.1111/pedi.12327. PubMed PMID: 27411431.
  • Hakola L, Takkinen HM, Niinistö S, Ahonen S, Erlund I, Rautanen J, Veijola R, Ilonen J, Toppari J, Knip M, Virtanen SM, Lehtinen-Jacks S. Maternal fatty acid intake during pregnancy and the development of childhood overweight: a birth cohort study. Pediatr Obes. 2016 Jul 5. doi: 10.1111/ijpo.12170. [Epub ahead of print] PubMed PMID: 27378525.
  • Löf C, Patyra K, Kuulasmaa T, Vangipurapu J, Undeutsch H, Jaeschke H, Pajunen T, Kero A, Krude H, Biebermann H, Kleinau G, Kühnen P, Rantakari K, Miettinen P, Kirjavainen T, Pursiheimo JP, Mustila T, Jääskeläinen J, Ojaniemi M, Toppari J, Ignatius J, Laakso M, Kero J. Detection of Novel Gene Variants Associated with Congenital Hypothyroidism in a Finnish Patient Cohort. Thyroid. 2016 Sep;26(9):1215-24. doi: 10.1089/thy.2016.0016. Epub 2016 Aug 2. PubMed PMID: 27373559; PubMed Central PMCID: PMC5036323.
  • Damsgaard J, Joensen UN, Carlsen E, Erenpreiss J, Blomberg Jensen M, Matulevicius V, Zilaitiene B, Olesen IA, Perheentupa A, Punab M, Salzbrunn A, Toppari J, Virtanen HE, Juul A, Skakkebæk NE, Jørgensen N. Varicocele Is Associated with Impaired Semen Quality and Reproductive Hormone Levels: A Study of 7035 Healthy Young Men from Six European Countries. Eur Urol. 2016 Dec;70(6):1019-1029. doi: 10.1016/j.eururo.2016.06.044. Epub 2016 Jul 14. PubMed PMID: 27423503.
  • Moulder R, Lahesmaa R. Early signs of disease in type 1 diabetes. Pediatr Diabetes. 2016 Jul; 17 Suppl 22:43-8. Review.
  • Toivonen R, Kong L, Rasool O, Lund RJ, Lahesmaa R, Hänninen A. Activation of plasmacytoid dendritic cells in colon-draining lymph nodes during Citrobacter rodentium infection involves pathogen-sensing and inflammatory pathways distinct from conventional dendritic cells. J Immunol. 2016 Jun 1;196(11):4750-9.
  • Konki M, Pasumarthy K, Malonzo M, Sainio A, Valensisi C, Söderström M, Emani MR, Stubb A, Närvä E, Ghimire B, Laiho A, Järveläinen H, Lahesmaa R, Lähdesmäki H, Hawkins RD, Lund RJ. Epigenetic silencing of the key antioxidant enzyme catalase in karyotypically abnormal human pluripotent stem cells. Sci Rep. 2016 Feb 25;6:22190. doi: 10.1038/srep22190.
  • Intosalmi J, Nousiainen K, Ahlfors H, Lähdesmäki H. Data-driven mechanistic analysis method to reveal dynamically evolving regulatory networks. Bioinformatics. 2016 Jun 15;32(12):i288-i296.
  • Äijö T, Huang Y, Mannerström H, Chavez L, Tsagaratou A, Rao A, Lähdesmäki H. A probabilistic generative model for quantification of DNA modifications enables analysis of demethylation pathways. Genome Biol. 2016 Mar14;17:49.
  • Yue X, Trifari S, Äijö T, Tsagaratou A, Pastor W, Zepeda-Martinez JA, Huang Y, Vijayanand P, Lähdesmäki H, Rao A. Control of Foxp3 stability through modulation of TET activity. J Exp Med. 2016 Mar 7;213:377-397.
  • Pedersen HK, Gudmundsdottir V, Nielsen HB, Hyotylainen T, Nielsen T, Jensen BA, Forslund K, Hildebrand F, Prifti E, Falony G, Le Chatelier E, Levenez F, Doré J, Mattila I, Plichta DR, Pöhö P, Hellgren LI, Arumugam M, Sunagawa S, Vieira-Silva S, Jørgensen T, Holm JB, Trošt K, Consortium M, Kristiansen K, Brix S, Raes J, Wang J, Hansen T, Bork P, Brunak S, Oresic M, Ehrlich SD, Pedersen O. Human gut microbes impact host serum metabolome and insulin sensitivity. Nature. 2016; 535:376-81.
  • Yassour M, Vatanen T, Siljander H, Hämäläinen A-M, Härkönen T, Ryhänen SJ, Franzosa EA, Vlamakis H, Huttenhower C, Gevers D, Lander ES, Knip M; DIABIMMUNE Study Group, Xavier, RJ. Natural history of the infant gut microbiome and impact of antibiotic treatment on bacterial strain diversity and stability. Sci Transl Med. 2016;8(343):343ra81. (Press release)
  • Vatanen T, Kostic AD, d'Hennezel E, Siljander H, Franzosa EA, Yassour M, Kolde R, Vlamakis H, Arthur TD, Hämäläinen AM, Peet A, Tillmann V, Uibo R, Mokurov S, Dorshakova N, Ilonen J, Virtanen SM, Szabo SJ, Porter JA, Lähdesmäki H, Huttenhower C, Gevers D, Cullen TW, Knip M; DIABIMMUNE Study Group, Xavier RJ. Variation in Microbiome LPS Immunogenicity Contributes to Autoimmunity in Humans. Cell. 2016. doi: 10.1016/j.cell.2016.04.007. (Press release)
  • Knip M, Siljander H. The role of the intestinal microbiota in type 1 diabetes mellitus. Nat Rev Endocrinol. 2016 Mar;12(3):154-67. doi: 10.1038/nrendo.2015.218.
  • Hamari S, Kirveskoski T, Glumoff V, Kulmala P, Simell O, Knip M, Veijola R. Analyses of regulatory CD4(+) CD25(+) FOXP3(+) T cells and observations from peripheral T cell subpopulation markers during the development of type 1 diabetes in children. Scand J Immunol. 2016 Feb 17. doi: 10.1111/sji.12418.
  • Juusola M, Parkkola A, Härkönen T, Siljander H, Ilonen J, Åkerblom HK, Knip M; Childhood Diabetes in Finland Study Group. Positivity for Zinc Transporter 8 Autoantibodies at Diagnosis Is Subsequently Associated With Reduced β-Cell Function and Higher Exogenous Insulin Requirement in Children and Adolescents With Type 1 Diabetes. Diabetes Care. 2016 Jan;39(1):118-21. doi: 10.2337/dc15-1027.
  • Mäkinen M, Mykkänen J, Koskinen M, Simell V, Veijola R, Hyöty H, Ilonen J, Knip M, Simell O, Toppari J. Serum 25-Hydroxyvitamin D Concentrations in Children Progressing to Autoimmunity and Clinical Type 1 Diabetes. J Clin Endocrinol Metab. 2016 Feb;101(2):723-9. doi: 10.1210/jc.2015-3504
  • Koskinen MK, Helminen O, Matomäki J, Aspholm S, Mykkänen J, Mäkinen M, Simell V, Vähä-Mäkilä M, Simell T, Ilonen J, Knip M, Veijola R, Toppari J, Simell O. Reduced β-cell function in early preclinical type 1 diabetes. Eur J Endocrinol. 2016 Mar;174(3):251-9. doi: 10.1530/EJE-15-0674.
  • Tuomela S, Rautio S, Ahlfors H, Öling V, Salo V, Ullah U, Chen Z, Hämälistö S, Tripathi SK, Äijö T, Rasool O, Soueidan H, Wessels L, Stockinger B, Lähdesmäki H, Lahesmaa R. Comparative analysis of human and mouse transcriptomes of Th17 cell priming. Oncotarget. 2016 Mar 7. doi: 10.18632/oncotarget.7963.
  • Jørgenrud B, Stene LC, Tapia G, Bøås H, Pepaj M, Berg JP, Thorsby PM, Orešič M, Hyötyläinen T, Rønningen KS. Longitudinal plasma metabolic profiles, infant feeding, and islet autoimmunity in the MIDIA study. Pediatr Diabetes. 2016 Jan 21. doi: 10.1111/pedi.12360.
  • Hyötyläinen T, Jerby L, Petäjä EM, Mattila I, Jäntti S, Auvinen P, Gastaldelli A, Yki-Järvinen H, Ruppin E, Orešič M. Genome-scale study reveals reduced metabolic adaptability in patients with non-alcoholic fatty liver disease. Nat Commun. 2016 Feb 3;7:8994. doi: 10.1038/ncomms9994.
  • Marinković T, Orešič M. Modeling strategies to study metabolic pathways in progression to type 1 diabetes - Challenges and opportunities. Arch Biochem Biophys. 2016 Jan 1;589:131-7. doi: 10.1016/j.abb.2015.08.011.

2015 [Top]

2014 [Top]

2013 [Top]

2012 [Top]